15 results for “Owens-Illinois”
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Medical study · Medical research · 2023
The lung cancers: staging and response, CT, 18F-FDG PET/CT, MRI, DWI: review and new perspectives
This was a review, not an original study; it reported no new study results, and its patient images were illustrative examples. The authors reviewed how CT, 18F-FDG PET/CT and MRI are used to stage lung cancer and to judge response to treatment, in…
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Medical study · Medical research · 2021
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
This laboratory study did not involve asbestos or people with mesothelioma. It concerned uveal melanoma, an eye cancer, and the gene BAP1, which the authors note is also mutated in mesothelioma and other cancers. The authors looked for drugs that…
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Medical study · Medical research · 2021
Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities
This was a laboratory study, not a study of asbestos-exposed people. The authors studied two enzymes in human malignant pleural mesothelioma (MPM) cell lines and tumor samples: COX-2, linked to inflammation, and aromatase (CYP19A1), which makes…
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Medical study · Medical research · 2025
Trends in Pleural Mesothelioma Incidence and Survival in Metropolitan and Nonmetropolitan Areas in the United States
This was a retrospective study of US cancer registry data (SEER 18 registries, covering about 34% of the US population). It compared pleural mesothelioma in metropolitan and nonmetropolitan counties. It included 8519 patients aged 20 or older…
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Medical study · Medical research · 2025
Trends in Mesothelioma Mortality in the United States Between 1999 and 2020
This study used the CDC WONDER national death-certificate database to examine U.S. mesothelioma deaths from 1999 to 2020. It did not measure anyone's asbestos exposure or occupation. There were 54,905 mesothelioma deaths, an age-adjusted rate of 7.5…
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Medical study · Medical research · 2021
Asbestos containing materials in schools of Rome and surrounding area (Italy)
…vinyl floor tiles. Forty also had friable ACM, such as boiler insulation, linings of laboratory ovens and centrifuges, and Bunsen burner gauze mats. Crocidolite with chrysotile was found in about 80% of roofing samples, and vinyl…
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Medical study · Medical research · 2024
Specific Targeting of Mesothelin-Expressing Malignant Cells Using Nanobody-Functionalized Magneto-Fluorescent Nanoassemblies
…3D cell clusters, particles reached only the outer layers. Under flow, they bound almost only to mesothelin-expressing cells. The authors concluded that the approach opens prospects for delivering drugs specifically to mesothelin-expressing cancer cells.
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Medical study · Medical research · 2020
Induction of Gamma-Glutamyltransferase Activity and Consequent Pro-oxidant Reactions in Human Macrophages Exposed to Crocidolite Asbestos
Asbestos is the main causative agent of malignant pleural mesothelioma. The variety known as crocidolite (blue asbestos) owns the highest pathogenic potential, due to the dimensions of its fibers as well as to its content of…
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Medical study · Medical research · 2021
Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
…of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.
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Medical study · Medical research · 2020
Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody-Drug Conjugate
…increased binding of AM1 to EGFR-positive tumor cells, opens the possibility to target a wide array of tumors beyond those with high levels of EGFR overexpression or amplification, including those insensitive to auristatin-based ADCs…
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Medical study · Medical research · 2021
Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques
…Fe content in the ABs was higher than that possibly contained in chrysotile and crocidolite. This finding opens two opposite scenarios, the first with Fe coming from the fiber bulk and concentrating on the surface as…
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Medical study · Medical research · 2020
A new trajectory approach for investigating the association between an environmental or occupational exposure over lifetime and the risk of chronic disease: Application to smoking, asbestos, and lung cancer
…dose and the timing of exposure. The proposed approach opens new perspectives for the analyses of dose-time-response relationships between protracted exposures and the risk of developing a chronic disease, by providing a complete picture…
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Medical study · Medical research · 2021
Pathological Characterization of Tumor Immune Microenvironment (TIME) in Malignant Pleural Mesothelioma
…a greater understanding of the pathogenetic mechanisms in tumor development and pathobiology of TIME, that opens the way to new therapeutic strategies. The study of TIME is fundamental in identifying appropriate prognostic and predictive tissue biomarkers…
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Medical study · Medical research · 2020
Inhibitors of cytoskeletal dynamics in malignant mesothelioma
…species. One of these, imipramine blue, was particularly effective in counteracting some key malignant properties of highly invasive MM cells. This opens a new possibility for targeted inhibition of MMs based on well-established molecular mechanisms.
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Medical study · Medical research · 2025
Nitric Acid Leaching for Magnesium Extraction from Asbestos Ore Waste: From DoE to Predictive Modeling and Cost-Efficient Optimization
…can be achieved while reducing reagent use and lowering the overall cost of magnesium production. Leaching of magnesium by HNO3 also opens a pathway to a closed-cycle process, due to the formation of magnesium nitrate…