Well-differentiated papillary mesothelial tumour: a rare finding on the pleura

Our plain-English summary of Well-differentiated papillary mesothelial tumour: a rare finding on the pleura, by L. Rostock, O. Holotiuk, T. Ploenes (Thorax, 2024).

The study

• Authors: L. Rostock, O. Holotiuk, T. Ploenes
• Journal: Thorax
• Published: 2024;79(4):380-381
• Cited by: 1 article, as counted by NIH iCite
• Read it: PubMed · Publisher · Free full text

In plain English

This article was a short case report in the journal's "Images in Thorax" series. It described one woman, aged 72, who went to an emergency department with intermittent abdominal pain. She reported no exposure to asbestos. She had quit smoking in 1975 after smoking two cigarettes per day for 6 years. A CT scan of the abdomen found nothing to explain the pain, but it showed an unrelated mass near the diaphragm. During thoracoscopy (a keyhole examination of the chest), the surgeons found a tumour on a stalk attached to the pleura covering the diaphragm. The rest of the pleura looked normal. The tumour was removed, and her recovery after surgery was uneventful. Tissue examination identified it as a well-differentiated papillary mesothelial tumour. Laboratory stains were positive for Wilms tumour gene 1, calretinin, cytokeratin 5/6, and cytokeratins 7 and 8, and negative for cytokeratin 20 and thyroid transcription factor 1. The authors presented the tumour as a rare finding on the pleura. Because this is a report of one patient, it does not show how often such tumours occur or what causes them.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (single patient, "Images in Thorax")
• Who was studied: one 72-year-old woman seen at an emergency department with abdominal pain; authors based at thoracic surgery and pathology departments in Coswig and Dresden, Germany
• Exposure: the patient reported no exposure to asbestos; former smoker of two cigarettes per day for 6 years, quit in 1975
• Main results:
  • A CT scan of the abdomen showed no cause for her symptoms but showed an incidental mass near the diaphragm
  • Thoracoscopy found a pedunculated (stalked) tumour of the diaphragmatic pleura; the remaining pleura looked unaltered
  • The tumour was resected and the postoperative course was uneventful
  • Histopathology showed a well-differentiated papillary mesothelial tumour, positive for Wilms tumour gene 1, calretinin, cytokeratin 5/6 and cytokeratins 7 and 8, and negative for cytokeratin 20 and thyroid transcription factor 1
• The authors' conclusion: The authors presented the well-differentiated papillary mesothelial tumour as a rare finding on the pleura

Topics

The National Library of Medicine indexes this study under subjects our site covers: Mesothelioma.

Medical terms in this study, explained in our Lexicon: Well-Differentiated, Pleura.

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• Well differentiated papillary mesothelioma of abdomen- a rare case with diagnostic dilemma — A. Saha, P.K. Mandal, et al. (2018)
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• A Case of Solitary Well-Differentiated Papillary Mesothelioma with Invasive Foci in the Pleura — S. Shimizu, H.E. Yoon, et al. (2017)
• Clinical Characteristics and Outcomes of Patients with Well-Differentiated Papillary Peritoneal Mesothelial Tumors — M. Offin, N. Aguirre, et al. (2024)

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