Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report

Our plain-English summary of Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report, by T. Miyata, H. Nishiki, Y. Shinden, et al (Clinical Case Reports, 2023).

The study

• Authors: T. Miyata, H. Nishiki, Y. Shinden, S. Motoyama, Y. Sannomiya, H. Tamezawa, T. Nagayama, R. Kin, A. Hashimoto, D. Kaida, Y. Tomita, N. Nakamura, T. Miyashita, H. Fujita, N. Ueda, H. Takamura
• Journal: Clinical Case Reports
• Published: 2023;11(5):e7383
• Type of article: Case report
• Cited by: 1 article, as counted by NIH iCite
• Read it: PubMed · Publisher · Free full text

Abstract

Key Clinical Message: Malignant peritoneal mesothelioma, a rare and poor prognosis disease, is seldom treated surgically, especially for recurrence. However, early diagnosis and aggressive treatment of primary and recurrent tumors can achieve long-term patient survival.

Abstract: Malignant peritoneal mesothelioma (MPM) is a rare and aggressive tumor, and rarely indicated for surgery, especially for recurrence. In the present case, we report a rare case who could survive long-term after two surgeries in 4 years for MPM.

© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

In plain English

This case report described a 59-year-old Japanese woman treated at Kanazawa Medical University Hospital for malignant peritoneal mesothelioma, a cancer of the abdominal lining. The authors reported that she had no apparent source of asbestos exposure at work or at home. Three years and 11 months earlier, surgeons had removed one peritoneal mesothelioma touching the hepatoduodenal ligament, along with part of the liver, and three others on the diaphragm. She was then followed without chemotherapy. During follow-up, CT found a 15-mm tumor near the liver, and ultrasonography showed it pressing on the middle hepatic vein and the inferior vena cava. PET-CT showed a maximum standardized uptake value of 7.4. Surgeons removed the tumor with the left caudate lobe of the liver. It had not invaded those veins. Pathology confirmed a recurrence of epithelioid mesothelioma. She was discharged 10 days later without complications and received no further therapy. CT and PET-CT showed no sign of recurrence over the next 16 months. The authors concluded that early diagnosis and treatment, made possible by strict follow-up after surgery, are important in managing patients with this disease.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (single patient)
• Who was studied: One 59-year-old Japanese woman with recurrent malignant peritoneal mesothelioma, treated at Kanazawa Medical University Hospital, Japan
• Exposure: No apparent source of asbestos exposure at work or in her residence
• Main results:
  • The patient had previously had surgery for one peritoneal mesothelioma in contact with the hepatoduodenal ligament (hepatic left lateral segmentectomy) and partial diaphragmatic resections for three other mesotheliomas on the diaphragm, 3 years and 11 months before the current presentation.
  • Abdominal ultrasonography showed a smooth, round, 15-mm tumor compressing the middle hepatic vein and inferior vena cava. CT had shown a round hypervascular tumor near the stump of the left hepatic vein.
  • On PET-CT the tumor showed increased fluorodeoxyglucose uptake, with a maximum standardized uptake value of 7.4.
  • The surgeons performed tumorectomy with left caudate lobe resection. There was no invasion of the middle hepatic vein or inferior vena cava.
  • The pathological findings were similar to those of the original tumor. The final diagnosis was metachronous (later) recurrence of epithelioid malignant peritoneal mesothelioma.
  • The patient was discharged 10 days after surgery with no complications.
  • No adjuvant therapy was given after the second surgery.
  • There was no CT or PET-CT evidence of tumor recurrence in the following 16 months.
• The authors' conclusion: The authors concluded that early diagnosis and treatment, achieved through strict follow-up after surgery, are important in managing patients with malignant peritoneal mesothelioma.

Topics

Medical terms in this study, explained in our Lexicon: Peritoneal Mesothelioma, Prognosis.

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