Mesothelioma

Our plain-English summary of Mesothelioma, by M. Deraco (Cancers, 2021).

The study

• Author: M. Deraco
• Journal: Cancers
• Published: 2021;13(13)
• Type of article: Editorial
• Cited by: 5 articles, as counted by NIH iCite
• Read it: PubMed · Publisher · Free full text

Abstract

Malignant mesothelioma is a disease affecting serosal surfaces derived from the mesothelium comprising the pleura, peritoneum, pericardium, and tunica vaginalis testis [...].

In plain English

This article was a short editorial by one author, not a research study. It introduced a monograph, a collection of articles, on peritoneal mesothelioma, the form of mesothelioma that affects the lining of the abdomen. The author stated that the monograph's aim was to give an overview of current knowledge about this disease's epidemiology, diagnosis, treatment and biology. The editorial did not study any patients or workers and reported no new data. The incidence figures, case estimates and survival times it mentioned came from other published studies, which it cited. On asbestos, the author wrote that there "might be an association" between asbestos exposure and diffuse malignant peritoneal mesothelioma, and that the disease's causes are mostly unknown. The editorial named no fiber type and gave no exposure data. It also described a combined treatment of cytoreductive surgery and heated chemotherapy delivered into the abdomen (HIPEC). It said a recent international consensus statement regards this as the standard first treatment for selected patients with diffuse malignant peritoneal mesothelioma.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: Editorial introducing a monograph (a collection of articles) on peritoneal mesothelioma; no original research
• Who was studied: No study population. The editorial discusses peritoneal mesothelioma in general.
• Exposure: Asbestos is mentioned only as a possible association with diffuse malignant peritoneal mesothelioma (DMPM); no fiber types, jobs or doses are given
• Main results:
  • No original findings. Citing a recent International Consensus Statement, the editorial stated that cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is regarded as the gold-standard initial treatment in selected patients with malignant diffuse peritoneal mesothelioma (DMPM)
• The authors' conclusion: The author stated that the monograph's objective was to give a comprehensive overview of current data on the epidemiology, diagnostics, therapeutics and pathophysiology of peritoneal mesothelioma

Topics

Medical terms in this study, explained in our Lexicon: Mesothelioma, Serosal Surface, Mesothelium, Pleura, Peritoneum, Pericardium, Tunica Vaginalis.

Related studies

• Peritoneal mesothelioma: PSOGI/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up — S. Kusamura, V. Kepenekian, et al. (2021)
• Multi-institutional experience of diffuse intra-abdominal multicystic peritoneal mesothelioma — T.C. Chua, T.D. Yan, et al. (2011)
• The Role of Ki-67 and Pre-cytoreduction Parameters in Selecting Diffuse Malignant Peritoneal Mesothelioma (DMPM) Patients for Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) — S. Kusamura, P.A. Torres Mesa, et al. (2016)
• Cytoreductive surgery with selective versus complete parietal peritonectomy followed by hyperthermic intraperitoneal chemotherapy in patients with diffuse malignant peritoneal mesothelioma: a controlled study — D. Baratti, S. Kusamura, et al. (2012)
• Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma — R. Sciarrillo, A. Wojtuszkiewicz, et al. (2019)
• Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma — N. Zaffaroni, A. Costa, et al. (2007)

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