Malignant peritoneal mesothelioma with lymph node metastasis that originated in the transverse colon

Our plain-English summary of Malignant peritoneal mesothelioma with lymph node metastasis that originated in the transverse colon, by Y. Takehara, S. Endo, Y. Mori, et al (World Journal of Surgical Oncology, 2014).

The study

• Authors: Y. Takehara, S. Endo, Y. Mori, K. Nakahara, D. Takayanagi, S. Shimada, T. Omoto, C. Maeda, S. Mukai, E. Hidaka, F. Ishida, J. Tanaka, S.E. Kudo
• Journal: World Journal of Surgical Oncology
• Published: 2014;12:112
• Type of article: Case report
• Cited by: 8 articles, as counted by NIH iCite
• Read it: PubMed · Publisher · Free full text

Abstract

Background: We report an extremely rare case of resection of localized biphasic malignant peritoneal mesothelioma of the transverse colon.

Case Report: Computed tomography and magnetic resonance imaging in a 72-year-old man showed a tumor with enhanced borders consistent with the transverse colon. Colonoscopy showed ulcerative lesions in the transverse colon, but histological examination showed no malignancy. A gastrointestinal stromal tumor was strongly suspected, so an extended right hemicolectomy was performed. Histopathological examination showed that the tumor was a localized malignant peritoneal mesothelioma of the transverse colon. The patient did not receive postoperative chemotherapy and died 18 months after surgery.

Conclusions: The number of patients with malignant mesotheliomas is predicted to increase in the future both in Japan and in western countries. We report this case due to its probable usefulness in future studies pertaining to the diagnosis and treatment of malignant mesotheliomas.

In plain English

This article was a case report from a hospital in Yokohama, Japan. It described one 72-year-old man who had had surgery for rectal cancer 10 years earlier. His work and residence history showed no apparent exposure to asbestos. Scans showed a tumor around the transverse colon, with no abnormal findings in the chest or pleura. A colonoscopy biopsy found no tumor cells. Doctors suspected a gastrointestinal stromal tumor and removed part of the colon and part of the small bowel (ileum). The tumor measured 10 × 9 × 5 cm. Under the microscope it was a localized biphasic malignant peritoneal mesothelioma that had started in the outer lining of the transverse colon. Cancer had spread to 6 of the 16 lymph nodes removed. The patient did not receive chemotherapy after surgery. The tumor came back 7 months after surgery, and he died 18 months after surgery. The authors concluded that larger studies are needed and that this report would be useful for future diagnosis and treatment of the disease.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (single patient)
• Who was studied: One 72-year-old man with a history of surgically treated rectal cancer 10 years earlier, treated at Showa University Northern Yokohama Hospital, Japan
• Exposure: No apparent asbestos exposure in his occupational or residence history
• Main results:
  • CT showed no abnormal findings in the mediastinum or lungs and no pleural thickening or nodules
  • A gastrointestinal stromal tumor was suspected and surgery was performed: extended right hemicolectomy and partial ileal resection
  • The removed tumor measured 10 × 9 × 5 cm
  • The diagnosis was localized biphasic malignant peritoneal mesothelioma arising in the visceral fascia of the transverse colon
  • Metastasis was found in 6 of 16 dissected lymph nodes
  • Without postoperative chemotherapy, the cancer recurred 7 months after surgery and the patient died 18 months after surgery
• The authors' conclusion: The authors concluded that studies with more cases are needed to improve prognosis, and that this report would be useful for future clinical diagnosis and treatment of the disease.

Topics

The National Library of Medicine indexes this study under subjects our site covers: Colon cancer, Lung cancer, Mesothelioma, Peritoneal mesothelioma.

Medical terms in this study, explained in our Lexicon: Peritoneal Mesothelioma, Metastasis, Biphasic Mesothelioma, Chemotherapy, Mesothelioma.

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• Lymph node metastases in diffuse malignant peritoneal mesothelioma — D. Baratti, S. Kusamura, et al. (2010)
• Peritoneal malignant mesothelioma metastatic to supraclavicular lymph nodes — S. Zannella, M.A. Testi, et al. (2014)
• Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry — A. Arjona-Sanchez, O. Aziz, et al. (2021)
• Malignant pleural mesothelioma without asbestos exposure with distant metastasis in a peripheral lymph node: a case report — S. Kant, S.K. Verma, et al. (2008)
• Cytological Profile of a Case of Malignant Mesothelioma of Pleura with Supraclavicular Lymph Node Metastasis — P.V. Priya, S. Deepa, et al. (2017)

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