Localized malignant peritoneal mesothelioma presenting hepatohilar giant mass

Our plain-English summary of Localized malignant peritoneal mesothelioma presenting hepatohilar giant mass, by O. Kinoshita (Oxford Medical Case Reports, 2022).

The study

• Author: O. Kinoshita
• Journal: Oxford Medical Case Reports
• Published: 2022;2022(10):omac110
• Type of article: Case report
• Read it: PubMed · Publisher · Free full text

In plain English

This was a short case report, published as a clinical image, describing one patient treated at a hospital in Osaka, Japan. A 72-year-old woman with no history of occupational or environmental asbestos exposure came to the hospital with upper abdominal (epigastric) pain and loss of appetite. A CT scan showed a giant localized mass near the liver hilum, about 150 mm in size. A biopsy taken through the skin and liver led to a diagnosis of malignant peritoneal mesothelioma. She received six courses of chemotherapy with cisplatin plus pemetrexed. The tumor did not change in size, which was classed as stable disease. Because prolonged suppression of her bone marrow made further chemotherapy difficult, the tumor was removed surgically. It was encapsulated, arose from the right upper retroperitoneum, and pressed on nearby organs without invading them. No visible disease remained after surgery. Tests on the removed tissue confirmed epithelioid malignant peritoneal mesothelioma, with little sign of chemotherapy effect. She chose no further treatment, and no sign of recurrence was seen 60 months after surgery and chemotherapy. The author did not state a general conclusion.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (clinical image) of a single patient
• Who was studied: one 72-year-old woman treated in the Department of Digestive Surgery, Iseikai Hospital, Osaka, Japan
• Exposure: no history of occupational or environmental asbestos exposure; treatment was cisplatin plus pemetrexed chemotherapy followed by surgical removal of the tumour
• Main results:
  • CT showed a giant localized hepatohilar mass about 150 mm in size
  • Biopsy led to a diagnosis of malignant peritoneal mesothelioma
  • After six courses of cisplatin plus pemetrexed, the maximum tumour diameter did not change, classed as stable disease
  • Surgery was chosen because protracted myelosuppression made the planned chemotherapy difficult to give
  • The encapsulated tumour, arising from the right upper retroperitoneum, was removed by simple tumourectomy with no visible residual disease (CC-0)
  • The resected specimen showed epithelioid malignant peritoneal mesothelioma, with chemotherapy effect rarely seen
  • Immunohistochemical staining was positive for calretinin, D2-40 and CK5/6 and negative for BerEP4 and MOC31
  • The patient declined further treatment, and no sign of recurrence was observed 60 months after surgery and chemotherapy

Topics

Medical terms in this study, explained in our Lexicon: Peritoneal Mesothelioma.

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• Malignant mesothelioma presenting as a giant chest, abdominal and pelvic wall mass — Z.H. Shao, X.L. Gao, et al. (2011)
• Microcystic variant malignant mesothelioma presenting as a localized paraspinal mass — H.M. Ko, Z.S. Kamil, et al. (2014)
• Peritoneal mesothelioma presenting as an adnexal mass — R.A. Komorowski, D.H. Bobert (1975)
• Extra-gastrointestinal stromal tumor presenting as a huge peritoneal mass and mimicking as mesothelioma - A case report — D. Ghartimagar, A. Ghosh, et al. (2021)
• Benign multicystic peritoneal mesothelioma presenting as a ghost abdominal mass — H. Jerraya, W. Ghariani, et al. (2016)

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